The United States Penitentiary, Lee (USP Lee) is a high-security United States federal prison for male inmates in Virginia. It is operated by the Federal Bureau of Prisons, a division of the United States Department of Justice. The facility also has an adjacent satellite prison camp which houses minimum-security male offenders. USP Lee is located in the Lee County Industrial Park an unincorporated area in Lee County, Virginia, in the southwest part of the state. The prison is located off of U.S. Route 58 at the intersection of State Route 638, near Pennington Gap and east of Jonesville.