Yazoo County is a county located in the U.S. state of Mississippi. As of the 2010 census, the population was 28,065. The county seat is Yazoo City. It is named for the Yazoo River, whose name, legend has it, comes from an Indian word meaning “River of Death.” Yazoo County is included in the Jackson-Vicksburg-Brookhaven, MS Combined Statistical Area. It is located in the Mississippi Delta region. Farming and lumber are the predominant industries of Yazoo County.